Aspirin and Healthy Heart
You have high blood pressure or arteriosclerosis. One of the suggestions many doctors give, and now recommended by the American Heart Association as a standard component of maintaining a healthy heart, is adding low-dose aspirin to your daily regimen. Here is why.
Aspirin works by inhibiting the formation of prostaglandins by blocking an essential enzyme needed for their formation. Prostaglandins come from essential fatty acids meaning the body needs these particular fatty acids and that you must eat them. Your body cannot produce them. Aspirin’s ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme.
Cyclooxygenase is required for prostaglandin and thromboxane synthesis. Ultimately aspirin differs from other NSAIDs, such as diclofenac and ibuprofen, which are reversible inhibitors. Other benefits include the analgesic relief resulting in relaxing muscles and opening up blood vessels. A large number of heart attacks and strokes are caused by small, often spontaneously forming blood clots, and the ability of aspirin to prevent the formation of these small clots may mean heart attacks and stroke become less likely. While there is no clear research identifying that aspirin has a connection with blood pressure, the protective benefits are generally accepted.
Aspirin was isolated from willow bark hundreds of years ago and is now available in the form of aspirin. In terms of cost, availability and usefulness, it is one of the most successful achievements of modern science.
There are currently nine known prostaglandin receptors on various cell types. These varied receptors mean that Prostaglandins thus act on a variety of cells, and have a wide variety of actions:
- cause constriction or dilation in vascular smooth muscle cells
- cause aggregation or disaggregation of platelets
- sensitize spinal neurons to pain
- decrease intraocular pressure
- regulate inflammatory mediation
- regulate calcium movement
- control hormone regulation
- control cell growth
Some people should not take aspiring including those with allergies to another-aspirin line product, asthma, kidney disease, ulcers and gout. Some people are sensitive to aspirin while others may experience possible side effects which include:
- increased risk of bleeding
- stomach or intestine irritation
- hypersensitivity or toxicity (fortunately, there are other natural means of accomplishing some of the same benefits of aspirin)
1. ^ Jeffreys, Aspirin, pp. 223-226
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